For example, HAVCR2 CNVs were negatively correlated with infiltration of B cell, iTreg, Th1, nTreg, cytotoxic, and DC; LAG3 with Th17, NKT, and CD4+ T cell; LAYN with CD8 naive cell, neutrophil, MAIT and effector memory cells; PDCD1 with infiltration of DC, neutrophil, effector memory and B cells; and TIGIT with γδ, NKT and CD8 T cells in breast cancer (Table S7 and Figure 5E). The gene discussed is CD8A; the disease is breast cancer.