Chromatin modifier histone deacetylase 11 (HDAC11) serves as a dynamic epigenetic regulator in the lymph nodes microenvironment as demonstrated in breast cancer cells models, in which increased HDAC11 expression inhibits cell cycle suppressors E2F7 and E2F8, promoting tumorigenesis and growth in the lymph nodes while downregulation of HDAC11 upregulates RRM2, promoting migration and egress from lymph nodes to distant sites predominantly through the draining blood vessels of lymph nodes [210]. Here, HDAC11 is linked to breast carcinoma.