Strikingly, growing evidence supporting aberrant UBE3A activity [16] would contribute to the manifestations of an array of additional neurological disorders including schizophrenia [17], Huntington’s [18,19], Parkinson’s [20], and Alzheimer’s diseases [21,22,23], making UBE3A a protein of high research and clinical interest. Here, UBE3A is linked to early-onset autosomal dominant Alzheimer disease.