It is predicted (https://www.ndexbio.org/iquery/, accessed at 17 Feb 2025) that both UBE3A and APP are involved in pathways regulating neuronal/cellular responses to nerve growth factors, neural projection organization, learning, and locomotor skills (Figure 5B), all of which are frequently dysregulated in neurodevelopmental and neurodegenerative diseases. Here, UBE3A is linked to neurodegenerative disease.