Conversely, this tumor region displayed a significant increase in proteins essential for the structure, stability, and function of the ECM, including Collagen alpha-1(VI) (COL6A1), alpha-2(VI) (COL6A2), alpha-3(VI) (COL6A3), alpha-1(XIV) (COL14A1), alpha-2(I) (COL1A2), and alpha-1(I) (COL1A1) chains, along with other key ECM components, such as Fibrillin-1, EMILIN-1, Prolargin, and Lumican (Figure 3). This evidence concerns the gene COL6A3 and neoplasm.