The MLH1- and PMS2-expressing tumor area (A1) exhibited somatic variants in MDC1 (c.3557T>C, VAF 0.0213), TP53 (c.670G>T, VAF 0.768), and LZTR1 (c.353G>A and c.2317G>A; VAFs 0.0574 and 0.7586, respectively) (Table 2). The gene discussed is MLH1; the disease is neoplasm.