In addition, TLR-9 signaling has been related to MyD88 recruitment, followed by the activation of NF-κB, leading to acute lung injury and acute respiratory distress syndrome (ARDS) through the secretion of cytokines, which was consistent with our findings suggesting that sepsis induces inflammation by the synthesis of NF-κΒ and pro-inflammatory cytokines [45]. The gene discussed is NFKB1; the disease is Sepsis.