Of interest is the IL-17c production by epithelia, which promotes inflammatory responses in the skin and the gut that is downregulated in the OBO cohort but requires further investigation since the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicates a pro-inflammatory environment facilitating Inflammatory Bowel Disease (IBD), Systemic lupus erythematosus(SLE) and Rheumatoid Arthritis (RA)(Supplementary Figure S1D–F). Here, IL17C is linked to systemic lupus erythematosus.