Other proteins that were identified as downregulated in the OBO group remain underexplored in the context of their roles in metabolic syndrome and obesity, such as AXIN1, STAMBP, EIF4EBP1, CASP8, CA1, SOD1, GP1BA, NCAM1, KITLG, and ADA. This evidence concerns the gene CASP8 and obesity due to melanocortin 4 receptor deficiency.