TAM/M2 macrophages play an important role in tumor proliferation, invasion, angiogenesis, metastasis, and the immune suppression of the TME via secreting molecules (EGF, VEGF, PDGF, and FGF), cytokines (IL-10 and TGF-b), and chemokines (CCL17, CCL22, and CXCL8), as well as by inducing autocrine and paracrine pathways [32,33,34,35]. This evidence concerns the gene EGF and neoplasm.