ACHE and Alzheimer disease: Several in silico studies have reported the identification of active substances and anti-inflammatory mechanisms [20], coumarins and their derivatives, lignans, phenols, alkaloids [21], amides, among others, including diterpenes with structural and non-structural proteins of DENV, ZIKV, and CHIKV [22], Alzheimer’s disease [23], AChE, and BChE [24].