The cardiomyopathy-associated targets were Dnmt1, Hdac1, Dot1l, Setd5, Nsd2, Usp3, Bap1, Prkca, Prkcb, Crebbp and Clock: 11 out of 81 (13.6% of total targets) (Table 2). Here, DOT1L is linked to cardiomyopathy.