A potential crosstalk between SYNE1 and IL-1, IL-1β main receptor NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) or nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) could be one of the possible explanations of the association of SYNE1 and CAD shown in our study. The gene discussed is NFKB1; the disease is coronary artery disorder.