The primary genomic risk factors encompasses chromosomal translocations, gene fusions, and rearrangements including BCR:ABL1 t(9;22), TVF3::HLF fusion t(17;19), KMT2A rearrangement t(4;11), MEF2D rearrangement t(1;19), TCF3:HLF fusion, mixed-phenotype acute leukemia (MPAL), early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), and intrachromosomal amplification of chromosome 21 (iAMP21) [59]. The gene discussed is HLF; the disease is acute lymphoblastic leukemia.