The following keywords were used in the search: TLR, TLR1-10, obesity, adipose tissue, metabolic syndrome, metabolic disease, atherosclerosis, endothelial dysfunction, diabetes, insulin resistance, NAFLD, NASH, fibrosis, inflammation, oxidative stress, treatment, therapeutic, clinical trial, disease, mechanism, vascular disease, cancer. This evidence concerns the gene TLR1 and atherosclerosis.