The following keywords were used in the search: TLR, TLR1-10, obesity, adipose tissue, metabolic syndrome, metabolic disease, atherosclerosis, endothelial dysfunction, diabetes, insulin resistance, NAFLD, NASH, fibrosis, inflammation, oxidative stress, treatment, therapeutic, clinical trial, disease, mechanism, vascular disease, cancer. Here, TLR1 is linked to metabolic dysfunction-associated steatotic liver disease.