Further analysis of differentially expressed genes between wild-type (WT) and mutant samples revealed that genes downregulated in IDH1 mutants and upregulated in EGFR mutants were enriched in neoplastic-stemness cells, while those downregulated in ATRX mutants were found mainly in tumor-associated macrophages (TAMs) (Figure S12). Here, EGFR is linked to neoplasm.