APOE and Alzheimer disease: The all-in-one platform is another strategy used to achieve this goal [128,129,130]; studies have developed a compact bacterial clustered regularly interspaced palindromic repeat (CRISPR)/dCas9-based repressor system that has been shown to robustly silence the expression of apolipoprotein E4 (APOE4), a risk factor highly expressed in late-onset Alzheimer’s disease [127,131].