It is possible that the antibodies against PLA2R were already preformed because hepatocytes express PLA2R on their surface, and, in the course of hepatitis, chronic inflammation leads to the abnormal glycosylation of IgG4, which activates the lectin pathway and causes conformational changes in the structure of PLA2R on the surface of podocytes and epitope spreading. Here, PLA2R1 is linked to Hepatitis.