Additionally, Akerman’s group demonstrated that concomitant downregulation of lncRNA PLUTO and PDX1 (encoding a key β cell transcription factor) can be observed in islets from donors with T2DM or impaired glucose tolerance, and PLUTO knockdown reduced the contact between upstream enhancers and the PDX1 promoter [58], suggesting that PLUTO affects local 3D chromatin structure and consequently transcription of PDX1. Here, PDX1 is linked to Impaired glucose tolerance.