NFKB1 and metabolic disease: It is worth noting that the expression of key proteins, including TLR4, MyD88, NF-κB, and FOXO1, was significantly up-regulated in the liver tissues of db/db mice in the experimental group compared with that of the control group (p < 0.05), which not only confirms our theoretical hypothesis but also provides a strong support for an in-depth understanding of the molecular mechanism of metabolic disorders.