Similarly to our results, the NLRP3/caspase-1/IL-1β signaling pathway was inhibited by SKQ1 intervention to inhibit mitochondrial ROS, Reduce the expression of BAX, Bak, p53 proteins, inhibit cell apoptosis, and ultimately improve myocardial fibrosis, relieve myocardial damage, and protect cardiac function. This evidence concerns the gene BAX and Myocardial fibrosis.