Because high levels of GATA2 are linked to poor outcomes in myeloid malignancies [147,148,149,150,151] and GATA2 was among the genes most differentially regulated by HMGA1 [48], functional studies were performed to determine whether HMGA1 depends upon GATA2 and downstream networks for leukemic transformation in MPN models. Here, HMGA1 is linked to myeloproliferative neoplasm.