However, the incidence of these alterations is rare compared to germline variants that enhance the risk for acquiring an MPN driver mutation, such as those involving the JAK2 locus [110,111,112], or for developing a significant clinical phenotype in the setting of an acquired driver mutation, such as alterations in the gene encoding the IL6 receptor [113,114,115,116]. Here, JAK2 is linked to myeloproliferative neoplasm.