Given these striking results demonstrating a key role for HMGA1 in MPN leukemia, multiomics studies were performed in JAK2V617F AML cell lines to identify underlying mechanisms, including RNAseq, chromatin immunoprecipitation sequencing (ChIPseq), and chromatin accessibility studies (assay for transposase chromatin sequencing, or ATACseq) [48]. The gene discussed is HMGA1; the disease is acute myeloid leukemia.