NFKB1 and arthritic joint disease: Nuclear factor-κB (NF-κB) is a transcription factor that plays in a crucial role in regulating the inflammatory response; activated NF-κB p65 has been implicated in various inflammatory diseases, such as arthritis [15,16], colitis [17], neuroinflammation [18], periodontal inflammation [19], renal epithelial inflammation [20], or skin inflammation [21].