IFT88 and Hydrocephalus: Mice with motor cilia defects, caused by the deletion of the Ift88 gene (also called tg737, which is a homolog of the ciliated protein OSM5 in Caenorhabditis elegans and the flagellate component IFT88 in Chlamydomonas Rhine) [47], exhibit growth retardation and severe hydrocephalus, leading to an enlarged skull and increased cranial pressure [48].