Moreover, Sergio Hernandez-Diaz et al. have demonstrated, using Drosophila models, that also Endophilin-B (EndoB) is required for autophagosome biogenesis at the synapse, that EndoB functions downstream of EndoA and, finally, that the loss of EndoB blocks the autophagy induction promoted by the PD mutation LRRK2 G2019S [65]. This evidence concerns the gene LRRK2 and Parkinson disease.