This study did not observe an association between the methylation levels of the ACE2 promoter and the genotypes of five COVID-19-associated polymorphisms (e.g., ACE2 rs2285666 and rs2074192, TMPRSS2 rs12329760 and rs2070788, ACE1 rs1799752) in a cohort of previously hospitalized COVID-19 survivors during the first wave of the pandemic with post-COVID symptoms. The gene discussed is ACE2; the disease is COVID-19.