PDK1 and atherosclerosis: On the other hand, upregulation of miR-210-3p was found to have a proatherosclerotic role in the development of atherosclerosis by targeting 3-phosphoinositide-dependent protein kinase-1 (PDK1) and blocking the P13K/Akt/mTOR signaling pathway, leading to increased EC apoptosis in a mouse model of atherosclerosis induced by a high-fat diet (HFD) [79].