However, in our work, the most consistently prioritized genomic variant in MS was HLA-A*02:01, which belongs to the MHC class I. Remarkably, there is evidence of the independent association of HLA-A*02:01 and HLA-DRB1*15:01 with MS [46], with the former considered protective and the latter predisposing to the disease, aligning with the results of our work. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.