In the present study, the mRNA expressions of c-Kit, Cx43, smMLCK,and myosin light chain 3 (MLC-3) in the colon of rotenone-induced PD mice were respectively reduced by 68.7%, 55.26%, 47.12% and 49.04 (Figure 3E–H, p < 0.05). This evidence concerns the gene GJA1 and Parkinson disease.