Pterostilbene alleviates constipation in slow constipated rats by reducing Interstitial Cell of Cajal (ICC) apoptosis through activation of the PI3K-AKT signaling pathway [11]; Electroacupuncture also promotes autophagy in enteric neuroglia through activation of the PI3K/AKT/mTOR signaling pathway, thereby alleviating functional constipation in mice [12]. This evidence concerns the gene AKT1 and intrahepatic cholangiocarcinoma.