From these, 62 were excluded for not evaluating leptin levels associated with low BMD, 38 for not evaluating the influence of leptin on bone mass, 36 including postmenopausal women, 5 focused on changes in BMD in anorexia nervosa patients, 1 focused on bone loss after bariatric surgery, 1 focused on changes in BMD in lipodystrophy, and 10 for not having available full text (Figure 1). This evidence concerns the gene LEP and anorexia nervosa.