Lactate dehydrogenase (LDH) was in positive correlation with the clinical stage (ρ = 0.283, 95% CI = 0.079–0.464, p = 0.006), IPI (ρ = 0.356, 95% CI = 0.159–0.525, p = 0.0004), bulky disorder (ρ = 0.3158, 95% CI = 0.079–0.464, p = 0.002), and ECOG PS (ρ = 0.2076, 95% CI = −0.001–0.399, p = 0.045), but in negative correlation with IL-8 (ρ = −0.3142, 95% CI = −0.568–−0.006, p = 0.04) in DLBCL without thrombosis. This evidence concerns the gene CXCL8 and diffuse large B-cell lymphoma.