When stimulated with low-density lipoprotein, Tet2-deficient macrophages in atherosclerotic plaque produce more IL-1 and IL-6 compared to macrophages without Tet2 mutations [27,61], suggesting that hypercholesterolaemia may intensify the proinflammatory effects of CHIP. The gene discussed is STUB1; the disease is Hypercholesterolemia.