The ensuing studies have established a significant link between CHIP and an elevated risk of CVD, including coronary artery disease (CAD) (HR 1.8–2.0), ischaemic stroke (HR 2.6), and premature myocardial infarction (HR 4.0), independent of traditional cardiovascular risk factors [27,28,32]. This evidence concerns the gene STUB1 and coronary artery disorder.