SOD1 and amyotrophic lateral sclerosis: Then, RS• can interact with NO to form S-nitrosylated cysteine residues in proteins, or undergo hyper-oxidation, to produce sulfinic and sulfonic cysteine after interaction with H2O2, ONOO−, and HOCl, which are irreversible (Figure 18) [351], as seen in the irreversible oxidation of SOD1 Cys111 to its sulfinic and sulfonic states, present in ALS mice models that presented signs of peripheral pain [352,353,354].