Finally, NOX4 was detected in dorsal horn neurons and interneurons of the spinal cord, as well as in the injured nerve and DRG in peripheral nerve injury and diabetic neuropathy [114,115], contributing to ROS production, peripheral myelin integrity impairment through myelin protein zero (MP) and peripheral myelin protein 22 (PMP22) degradation, associated with apoptosis, and consequently, the exacerbation of the manifestations of neuropathic pain, all of which were reduced when NOX4 activity was inhibited in knock-out mice [116]. Here, NOX4 is linked to peripheral nerve injury.