Recent research on COVID-19 highlights a relationship of the DSP gene with the lncRNA PIRAT (PU.1-induced regulator of alarmin transcription) that, during SARS-CoV-2 infection, drives the expression of alarmin S100A8 and S100A9, which together promote the differentiation of monocytes to macrophages and contribute to myeloid imbalances during severe COVID-19 [31]. The gene discussed is SPI1; the disease is COVID-19.