Although GDF15 has been related to chronic liver diseases [23,24,25], including some aspects of MASH such as hepatic fibrosis and liver stiffness [25], the potential relationship between circulating levels of GDF15 and key features of MASLD predisposing to atherosclerotic CV disease has not been fully explored. The gene discussed is GDF15; the disease is metabolic dysfunction-associated steatotic liver disease.