Additionally, dysregulated CXCR4 expression and a C-terminally truncated constitutive active CXCR4 mutant are major prognostic biomarkers for the relatively indolent lymphomas such as the germinal center B cell type (GCB)-DLBCL and lymphoplasmacytic lymphoma (LPL) or WM [15,19,20], respectively. This evidence concerns the gene CXCR4 and lymphoplasmacytic lymphoma.