BAK1 and cancer: While in cancer cell lines Bcl-2 interacts with Bax/Bak, inhibiting apoptosis [51], Bax/Bak accumulation in the external mitochondrial membrane induced by cytotoxic conditions is inhibited when Bad is attached to Bcl-2 or co-activators from the BH3 family’s domains (Bid, Bim, PUMA, etc.)[52].