While previous studies have demonstrated that inhibition of TGFβ activity attenuates the development of renal fibrosis in various animal models of renal fibrosis [5,6,7], due to its physiological importance, complete inhibition of the TGFβ signaling pathway is associated with deleterious side-effects, as has been shown in mice with genetic deletion of the TGF-β1 gene [8,9,10]. This evidence concerns the gene TGFB1 and renal fibrosis.