Assessment of urinary titin levels in POD1 is predictive of long-term skeletal muscle atrophy; future developments will clarify the effects of interventions such as early postoperative nutrition and rehabilitation interventions for patients with high titin levels and more precise nutrition and rehabilitation follow-up after discharge from the hospital in order to confirm the clinical significance of measuring titin in gastrointestinal cancer patients. This evidence concerns the gene TTN and Skeletal muscle atrophy.