By conducting a combined integrative and bioinformatic analysis of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) datasets, Deb and colleagues [89] discovered that NEK2 and Aurora kinase A are the most activated kinases among the five common human cancers (ovarian cancer, breast cancer, colon cancer, lung adenocarcinoma, and endometrial cancer). Here, NEK2 is linked to malignant colon neoplasm.