TP53 and cancer: Additionally, ncRNA species such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) also have roles as epigenetic regulators in CRC and are implicated in many cancer-related pathways, including the Wnt/β-catenin, RAS/MAPK, p53, TGF-β, and PI3K/AKT signaling pathways [21].