To identify transcriptional alterations that occur in cancer cells upon exposure to hepatocytes, we performed bead isolation using antibodies against CD326 (EpCAM) to isolate the SW480 tumor cells grown in the presence and absence of hepatocytes and supporting J2s, and we performed bulk RNA-seq analysis to identify genes and pathways that are modulated when exposed to hepatocytes. This evidence concerns the gene EPCAM and cancer.