We have shown that the tested compounds, BLU-258 and CR-BLU-258, had a cytostatic and cytotoxic effect on pancreatic cancer cells (PANC-1 and BxPC3 lines), reduced their migration, and affected the level of phosphorylation of the Akt and Erk1/2 proteins. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.