Indeed, Wu et al. [177] have indicated that Vitamin B6 is a cofactor associated with enzymes, like serine hydroxymethyltransferase (SHMT), methionine synthase reductase (MTRR), and methionine synthase (MS) and that it also plays a regulatory role in regulating genomic stability and cell viability in breast cancer patients. The gene discussed is MTRR; the disease is breast cancer.