DNM1L and HIV infectious disease: Zidovudine (AZT), a key component of some antiretroviral therapy regimens used to treat HIV infection, and its active metabolite AZT-triphosphate, exert their antiviral effect by upregulating the expression of Drp1 and Mff, the translocation of Drp1, and downregulating the expression of Opa1 to induce mitochondrial fission–fusion imbalance [124].