Through the gene score and function (enriched GO terms of DEGs are shown in Supplementary Figure S3), a correlation analysis of hub gene expression with the HF developmental phenotype and HF apoptosis (Figure 2c), and an interaction and network analysis (Figure 2e), we found that the key genes JUN and FOS play crucial roles on offspring HF development after maternal MT implantation. The gene discussed is JUN; the disease is hydrops fetalis.