STAT3 and central nervous system cancer: Additionally, studies have shown that 6’s anti-GBM effect may be due to inactivating the PKCδ/STAT3 signaling pathways [49], triggering cytotoxic autophagy in glioma cells by suppressing PI3K/AKT/mTOR [50] and enhancing TMZ’s pro-apoptotic effect via NF-κB modulation [51].