With the deep study of TBK1, it has also been found that TBK1 participates in IRF7, AKT, MAPK, mTOR, RIPK, and other signaling pathways, which regulate immune response, inflammation, metabolism, autophagy, apoptosis, cell proliferation, mitosis, and insulin signaling, thus playing a wide range of roles in the pathogenesis of autoimmune, inflammatory and metabolic diseases, and cancer [21,22,23,24,25,26,27]. Here, TBK1 is linked to metabolic disease.