TBK1 is a key signaling kinase involved in the regulation of inflammation and innate immunity, closely associated with the pathogenesis of IMIDs, such as rheumatoid arthritis (RA), autoinflammatory arthritis, ulcerative colitis (UC), systemic lupus erythematosus (SLE), asthma, and multiple sclerosis (MS) [11,74,75,76,77,78,79]. This evidence concerns the gene TBK1 and asthma.