To investigate the role of 15-hydroxyprostaglandin dehydrogenase (HPGD) in regulating cell proliferation and tumor growth, we stably transduced three human triple-negative breast cancer (TNBC) cell lines—MDA-MB231, MDA-MB436, and MDA-MB468—with lentiviral vectors carrying HPGD. Here, HPGD is linked to neoplasm.