For example, while established risk factors like fibroblast growth factor-19 and interleukin-6 are increased in aortic stenosis, two-step Mendelian randomisation analyses have demonstrated a diminished causal role for these inflammatory proteins when assessed in conjunction with other lipid parameters, including triacylglycerols, sterols, and phosphatidylcholines [62]. The gene discussed is IL6; the disease is aortic stenosis.