In the Supplemental Material, the classical model of depression—the chronic unpredictable mild stress dataset (GSE151807)—was utilized to perform WGCNA with IL-33-overexpression mouse differential genes (Figure S1 of Supplementary Material), and the blue module was selected as being positively correlated with the control group and WT daytime traits and negatively correlated with the IL-33-overexpression group, model group, and night group. This evidence concerns the gene IL33 and major depressive disorder.