IL-33-overexpression, a model of CUMS (chronic unpredictable mild stress), and genes associated with circadian traits are enriched in pathways related to mitochondrial functions, such as metabolism, and are associated with Huntington’s disease, Parkinson’s disease, neurodegeneration pathways, amyotrophic lateral sclerosis, and prion diseases. The gene discussed is IL33; the disease is Huntington disease.