The contribution that neuroinflammation makes to CNS pathologies associated with ME/CFS comes from positron emission tomography (PET) brain imaging using a radioligand for the translocator protein (TSPO), a protein belonging to the mitochondrial permeability transition pore (MPTP) complex and produced by activated microglia [71]. The gene discussed is TSPO; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.