Indeed, HCT116 is a wild-type p53 colon-cancer cell line (with a functional p53 protein), whereas the HT29 cell line carries a p53 mutation, which may lose its ability to trigger apoptosis in response to cellular stresses, such as treatment with chemotherapeutic drugs or other pro-apoptotic substances [64,65]. This evidence concerns the gene TP53 and colonic neoplasm.